Cell-Surface Association between Progelatinases and β2 Integrins: Role of the Complexes in Leukocyte Migration
نویسندگان
چکیده
REVIEW OF THE LITERATURE LEUKOCYTE ADHESION AND MIGRATION THE LEUKOCYTE MIGRATION CASCADE NEUTROPHIL FUNCTION AND ADHESION DURING INFLAMMATION Granulopoiesis and subsets of neutrophil granules INTEGRINS AND THEIR LIGANDS Structure and function of leukocyte β2 integrins Activation of leukocyte β2 integrins MATRIX METALLOPROTEINASES CLASSIFICATION OF MMPs STRUCTURAL FEATURES OF MMPs REGULATION OF MMPS Transcriptional regulation Zymogen activation Inhibition of enzymatic activity ROLE OF INTEGRINS AND MMPs IN LEUKOCYTE MIGRATION REGULATION OF LEUKOCYTE ADHESION AND MIGRATION CELL-SURFACE ASSOCIATION OF MMPs AND OTHER PROTEASES ROLE OF INTEGRINS AND GELATINASES IN CANCER AND INFLAMMATION INTEGRINS AND GELATINASES in tumor angiogenesis and growth INTEGRINS AND GELATINASES in invasion and metastasis INTEGRINS AND GELATINASES in cancer associated-inflammation ROLE OF INTEGRINS AND GELATINASES IN ACUTE LEUKEMIAS THERAPEUTIC INTERVENTION WITH MMP AND INTEGRIN INHIBITORS AIMS OF THE PRESENT STUDY MATERIALS AND METHODS
منابع مشابه
Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression.
Leukocyte motility is known to be dependent on both beta2-integrins and matrix metalloproteinases MMP-2/-9 or gelatinases, which mediate leukocyte adhesion and the proteolysis needed for invasion, respectively. Gelatinases not only play an important role in cell migration, tissue remodeling, and angiogenesis during development, but are also involved in the progression and invasiveness of many c...
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